{"id":5342,"date":"2023-04-20T15:35:36","date_gmt":"2023-04-20T13:35:36","guid":{"rendered":"https:\/\/itsbrain.mindpulse.net\/?page_id=5342"},"modified":"2023-04-26T15:19:11","modified_gmt":"2023-04-26T13:19:11","slug":"poster-depression-unipolaire-majeure","status":"publish","type":"page","link":"https:\/\/itsbrain.mindpulse.net\/en\/poster-depression-unipolaire-majeure\/","title":{"rendered":"Poster d\u00e9pression unipolaire majeure"},"content":{"rendered":"

[et_pb_section fb_built=\u00a0\u00bb1″ _builder_version=\u00a0\u00bb4.19.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bbRGBA(255,255,255,0)\u00a0\u00bb box_shadow_style=\u00a0\u00bbpreset6″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb4.19.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.19.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.19.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_text_color=\u00a0\u00bb#151E66″ header_2_font=\u00a0\u00bb|700|||||||\u00a0\u00bb header_2_text_color=\u00a0\u00bb#151E66″ header_2_font_size=\u00a0\u00bb28px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n

Evaluation of<\/h2>\n

attentional\/executive difficulties<\/h2>\n

in unipolar major depression : a preliminary study<\/h2>\n

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Rayss\u00e9guier C., Vancappel A., Suarez S., El Hage W<\/em><\/p>\n

L'Encephale, January 2023<\/em><\/p>\n

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Context:<\/span><\/h3>\n

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Context Presentation:<\/strong><\/strong><\/h4>\n

<\/strong><\/p>\n

    \n
  • Executive functions are generally impaired in unipolar major depression.<\/strong><\/li>\n
  • Current tools have difficulties specifying the impacted component in depression: need for more sensitive tools.<\/strong><\/li>\n
  • MindPulse is a computerized neuropsychological test that allows for a fine measurement of attentional and executive functions.<\/strong><\/li>\n<\/ul>\n

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    Objective of the study:<\/strong><\/h4>\n

     <\/p>\n

      \n
    • To assess executive and attentional deficits<\/strong> in unipolar major depression<\/li>\n
    • Validation of the MindPulse tool<\/strong> in a population with unipolar major depression<\/li>\n<\/ul>\n

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      The evaluation is conducted on 46 participants diagnosed with major depressive disorder (65% women), with a mean age of 38.5 years.<\/em><\/p>\n

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      Assessment of executive functions:<\/strong><\/p>\n

      \u00a0 \u00a0 \u00a0MindPulse<\/strong> (Decision-making)<\/p>\n

      \u00a0 \u00a0 \u00a0Stroop<\/strong> (inhibition)<\/p>\n

      \u00a0 \u00a0 \u00a0D2R<\/strong> (Sustained attention)<\/p>\n

      \u00a0 \u00a0 \u00a0TAP<\/strong> (Motor speed)<\/p>\n

      [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2″ _builder_version=\u00a0\u00bb4.19.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.19.5″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bbPoppins|300|||||||\u00a0\u00bb text_text_color=\u00a0\u00bb#151E66″ border_width_all=\u00a0\u00bb1px\u00a0\u00bb border_color_all=\u00a0\u00bb#4F669C\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n

      Symptomatology evaluation:<\/strong><\/p>\n

      \u00a0 \u00a0 MADRS<\/strong> (Depressive severity)<\/p>\n

      \u00a0 \u00a0 T2S<\/strong> (Psychological abilities)<\/p>\n

      \u00a0 \u00a0 ETE<\/strong> (Psychological difficulties)<\/p>\n

      \u00a0 \u00a0 ISI<\/strong> (Insomnia severity)<\/p>\n

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      Results<\/h2>\n

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      Correlation between questionnaires and cognitive tests<\/p>\n

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      *The correlation is significant at the 0.05 level (two-tailed).<\/em><\/p>\n

       <\/p>\n

        \n
      • Cognitive-affective symptoms of depression are positively
        correlated\nwith simple reaction time on the MindPulse (r=
        ,338, p =,05)<\/li>\n
      • Psychological competence in emotion identification is negatively
        correlated with simple reaction time on the
        Mindpulse. (r=-,303, p =
        ,05)<\/li>\n<\/ul>\n

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        CORRELATIONS BETWEEN COGNITIVE TESTS:<\/p>\n

        [\/et_pb_text][et_pb_image src=\u00a0\u00bbhttps:\/\/itsbrain.mindpulse.net\/wp-content\/uploads\/2023\/04\/image-54.png\u00a0\u00bb title_text=\u00a0\u00bbimage (54)\u00a0\u00bb _builder_version=\u00a0\u00bb4.20.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_margin=\u00a0\u00bb43px||||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00a0\u00bb4.20.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bbPoppins|300|||||||\u00a0\u00bb text_text_color=\u00a0\u00bb#151E66″ text_font_size=\u00a0\u00bb13px\u00a0\u00bb custom_margin=\u00a0\u00bb-29px||||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n

        *The correlation is significant at the 0.05 level (two-tailed); **The correlation is significant at the 0.01 level (two-tailed)<\/p>\n

         <\/p>\n

          \n
        • The indicators measured by Mindpulse are correlated with different indicators from other
          neuropsychological tests:
          - Simple reaction time is positively correlated with the error rate of D2R (r=0.376, p=0.05)
          - Go No Go is positively correlated with the error rate of D2R and negatively with the processing speed of D2R (r=0.390, p=0.01, r=-0.497, p=0.01)
          - Complex Go No Go is negatively correlated with the processing speed of D2R (r=-0.410, p=0.05)
          - Executive speed is negatively correlated with the processing speed of D2R (r=-0.394, p=0.01)
          - Reaction to difficulty is correlated with the number of interference errors in the Stroop test (r=-0.427, p=0.01).<\/li>\n<\/ul>\n

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          \n

          Example of a major depression case:<\/span><\/h2>\n<\/blockquote>\n

           <\/p>\n

          The 19-year-old patient is diagnosed with major depression (MADRS=26) and is under medication (Venlafaxine, Xanax). According to the STAI scales, anxiety levels are moderate (Y-A=49; Y-B=51). Regarding the symptomatology measured by ETE, the thresholds are pathological for both cognitive-affective (score=39) and physical (score=28) symptoms of depression, as well as for general anxiety symptoms (score=43). T2S informs us that the patient's planning skills (z-score=-3.02), emotion identification (z-score=-3.05), and problem-solving abilities (z-score=-2.25) are impaired. On the D2R, the patient shows a treatment style that is neither attentive nor focused (E%=97; CCT=69). On the Stroop, the scores are pathological, indicating difficulties in the C board of the Stroop (time=140sec, 90th percentile).<\/p>\n

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          Comparison of cognitive results from MindPulse between depressed patients and matched controls<\/strong><\/h3>\n

          A slowing down is observed in depressed patients at the perceptual-motor level (Simple Reaction Time) (t= 2.72, p=0.94%) and more pronounced at the executive level (Executive Slowdown t= 3.99, p=0.03%). This double slowdown is accompanied by a loss of precision (increase in total errors t= 2.97, p=0.48%, mainly an increase in inhibition and flexibility errors).<\/p>\n

          The Drift (Perception of Difficulty) of the Decision Diffusion Model (DDM) of the 2 Go\/NoGo tasks is significantly slower in depressed patients who require a higher rate of information accumulation towards the correct decision. This shows a more difficult adjustment process of decision-making and corresponds to data from the literature.<\/p>\n

          [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.20.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb min_height=\u00a0\u00bb304.5px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.20.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb header_2_font=\u00a0\u00bbPoppins|800|||||||\u00a0\u00bb header_2_text_color=\u00a0\u00bb#151E66″ box_shadow_style=\u00a0\u00bbpreset6″ box_shadow_color=\u00a0\u00bb#88B0D2″ global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n

          Conclusion<\/h2>\n

          [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.20.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_margin=\u00a0\u00bb-4px||||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.20.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.20.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_font=\u00a0\u00bbPoppins||on||||||\u00a0\u00bb text_text_color=\u00a0\u00bb#151E66″ custom_margin=\u00a0\u00bb-244px||||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb]<\/p>\n

            \n
          • Significant executive impairment in major unipolar depression population with executive slowing and selective attention<\/strong>
            deficit: better detection with Mindpulse<\/strong><\/li>\n
          • Existing links between symptomatology and Mindpulse test:<\/strong> links not found with other tools<\/li>\n
          • The study continues: inclusions are still ongoing<\/li>\n
          • Mindpulse data will benefit from profile analysis with the Decision Diffusion Model<\/strong> and Artificial<\/strong>
            Intelligence<\/strong> (AI) using a classifier AI (neural network).<\/li>\n<\/ul>\n

            [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","protected":false},"excerpt":{"rendered":"

            Evaluation des difficult\u00e9s attentionnelles\/ex\u00e9cutives dans la d\u00e9pression unipolaire majeure : une \u00e9tude pr\u00e9liminaireRayss\u00e9guier C., Vancappel A., Suarez S., El Hage W L’Enc\u00e9phale, janvier 2023Introduction :Pr\u00e9sentation du context : Les fonctions ex\u00e9cutives sont g\u00e9n\u00e9ralement alt\u00e9r\u00e9es dans la d\u00e9pression unipolaire majeure. 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